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Image Search Results
Journal: Genes
Article Title: Epigenetic Heterogeneity of B-Cell Lymphoma: DNA Methylation, Gene Expression and Chromatin States
doi: 10.3390/genes6030812
Figure Lengend Snippet: DNA methylation summary characteristics of lymphoma and of healthy B and GCB cells. ( a ) The frequency distribution of the promoter methylation beta values of B-cells shows two maxima referring to almost not- and completely methylated promoters, respectively; The distributions of beta values loose this bimodality to a large degree in lymphoma where weakly and intermediately methylated genes become hyper-methylated and highly methylated genes become hypo-methylated compared with healthy B-cells ( b + c ); ( d ) The total methylation level increases and ( e ) the variability of methylation among the genes in each of the samples decreases.
Article Snippet: Microarray-derived
Techniques: DNA Methylation Assay, Methylation
Journal: Genes
Article Title: Epigenetic Heterogeneity of B-Cell Lymphoma: DNA Methylation, Gene Expression and Chromatin States
doi: 10.3390/genes6030812
Figure Lengend Snippet: SOM portraying of the DNA methylation landscape of lymphoma (MetSOM). ( a ) SOM portraits of histological lymphoma classes and of controls. Red and blue colors assign regions containing genes with high and low methylation levels, respectively; ( b ) the methylation overview map summarizes regions hypermethylated in any of the classes compared with any other one in red. The methylation variance map identifies regions of highly variable (red) and almost invariant (blue) beta values; ( c ) The methylation profiles show the mean methylation level among the samples of genes taken from the “spot” regions 1–6 assigned in the methylation overview map. Horizontal dashed lines serve as guide for the eye showing the mean methylation level of the respective spot averaged over all samples. Assignments as “hyper-” or “hypomethylated” refer to relative methylations compared with B-cells. Lists of genes in these regions are given in .
Article Snippet: Microarray-derived
Techniques: DNA Methylation Assay, Methylation